The Human Sperm Head: A Key for Successful Fertilization
نویسندگان
چکیده
منابع مشابه
Participation of the sperm proteasome in human fertilization.
BACKGROUND Fertilization in mammals comprises the sequential interactions of the sperm with the cumulus oophorus, zona pellucida, and oocyte plasma membrane. Here we investigate proteasome activity in human sperm and its possible involvement during the fertilization process. METHODS Proteasome activity was measured in intact sperm and in sperm extracts using the fluorogenic substrate Suc-Leu-...
متن کاملSperm membrane physiology and relevance for fertilization.
This paper aims to overview recent insights in sperm surface remodelling pertinent to fertilization. A basic understanding of this remodelling is required to interpret the high amount of data appearing from high-throughput identification techniques for proteins presently applied in reproductive biology. From the extensive lists of protein candidates identified by proteomics, only a few are reco...
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Increasing attention has focused on the significance of RNA in sperm, in light of its contribution to the birth and long-term health of a child, role in sperm function and diagnostic potential. As the composition of sperm RNA is in flux, assigning specific roles to individual RNAs presents a significant challenge. For the first time RNA-seq was used to characterize the population of coding and ...
متن کاملSperm Flow Cytometry: Beyond Human Fertilization and Embryo Development
Male infertily is a contributing factor in up to 50% of all infertility cases, a solo cause in about 30% of them. Therefore, new and improved diagnostic methods that reduce operator variability regarding sperm defects that are not accesible by the conventional microscope scoring should be evaluated. Assisted reproductive technology (ART) has been involved in the description of alternative pathw...
متن کاملHuman sperm degradation of zona pellucida proteins contributes to fertilization
BACKGROUND The mammalian oocyte extracellular matrix known as the zona pellucida (ZP) acts as a barrier to accomplish sperm fusion with the female gamete. Although penetration of the ZP is a limiting event to achieve fertilization, this is one of the least comprehended stages of gamete interaction. Even though previous studies suggest that proteases of sperm origin contribute to facilitate the ...
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ژورنال
عنوان ژورنال: Journal of Andrology
سال: 2003
ISSN: 0196-3635
DOI: 10.1002/j.1939-4640.2003.tb02667.x